Antibiotic Resistance in Mycobacterium tuberculosis

DOI: 10.1074/jbc.m109.005546 Authors: Javier Suárez, Kalina Ranguelova, Johannes P. M. Schelvis, Richard S. Magliozzo Abstract: KatG (catalase-peroxidase) in Mycobacterium tuberculosis is responsible for activation of isoniazid (INH), a pro-drug used to treat...

Calcium modulates the rapid kinetics of the odorant-induced cyclic AMP signal in rat olfactory cilia

DOI: 10.1523/jneurosci.15-01-00310.1995 Authors: D. E. Jaworsky, Osamu Matsuzaki, FF Borisy, GV Ronnett Abstract: Although the cAMP and phosphoinositide (PI) second messenger systems are involved in olfactory signal transduction, aspects of their roles remain unclear....

Characterization of the W321F mutant of Mycobacterium tuberculosis catalase–peroxidase KatG

DOI: 10.1110/ps.09902 Authors: Shengwei Yu, Salem Chouchane, Richard S. Magliozzo Abstract: A single amino acid mutation (W321F) in Mycobacterium tuberculosis catalase-peroxidase (KatG) was constructed by site-directed mutagenesis. The purified mutant enzyme was...

Recent XAS studies into Homogeneous metal catalyst in fine chemical and pharmaceutical syntheses

DOI: 10.1186/s13065-015-0103-6 Authors: Grant J. Sherborne, Bao N. Nguyen Abstract: A brief review of studies using X-ray Absorption Spectroscopy (XAS) to investigate homogeneous catalytic reactions in fine chemical and pharmaceutical context since 2010 is presented....

The mechanism of methane and dioxygen activation in the catalytic cycle of methane monooxygenase

DOI: 10.1016/0014-5793(95)00195-f Authors: A. A. Shteinman Abstract: The binuclear structure of the active center of methane monooxygenase plays a determining role in dioxygen activation and in selectivity and specificity of alkane oxidation with this enzyme. A new...

In Situ Structural Observation of a Substrate- and Peroxide-Bound High-Spin Ferric-Hydroperoxo Intermediate in the P450 Enzyme CYP121

DOI: 10.1021/jacs.3c04991 Authors: Romie C. Nguyen, Ian Davis, Medhanjali Dasgupta, Yifan Wang, Philipp S. Simon, Agata Butryn, Hiroki Makita, Isabel Bogacz, Kednerlin Dornevil, Pierre Aller, Asmit Bhowmick, Ruchira Chatterjee, In‐Sik Kim, Tiankun Zhou, Derek Mendez,...

Reaction of Mycobacterium tuberculosis Truncated Hemoglobin O with Hydrogen Peroxide

DOI: 10.1074/jbc.m609155200 Authors: Hugues Ouellet, Kalina Ranguelova, Marie Labarre, Jonathan B. Wittenberg, Beatrice A. Wittenberg, Richard S. Magliozzo, Michel Guertin Abstract: In this work, we investigated the reaction of ferric Mycobacterium tuberculosis...

Trapping intermediates in metal transfer reactions of the CusCBAF export pump of Escherichia coli

DOI: 10.1038/s42003-018-0181-9 Authors: Kelly N. Chacón, Jonathan C. Perkins, Zachary Mathe, Katherine B. Alwan, Ethan N. Ho, Melek N. Ucisik, Kenneth M. Merz, Ninian J. Blackburn Abstract: Escherichia coli CusCBAF represents an important class of bacterial efflux...

Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes

DOI: 10.1021/jacs.2c12664 Authors: Lide Cha, Jared C. Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo, Wei‐chen Chang Abstract: Aziridines are compounds with a nitrogen-containing three-membered ring. When it is incorporated into natural products, the...

Spectroscopic capture of a low-spin Mn(IV)-oxo species in Ni–Mn3O4 nanoparticles during water oxidation catalysis

DOI: 10.1038/s41467-020-19133-w Authors: Sunghak Park, Kyoungsuk Jin, Hyung‐Kyu Lim, Jin Kim, Kang Hee Cho, Seungwoo Choi, Hongmin Seo, Moo Young Lee, Yoon Ho Lee, Sangmoon Yoon, Miyoung Kim, Hyungjun Kim, Sun Hee Kim, Ki Tae Nam Abstract: High-valent metal-oxo...