« In vitro » study of the mode of action of antidepressants in cell culture models : comparison of the effects of « Hypericum perforatum L. » extracts and classical synthetic compounds on the [beta]-adrenergic signal pathway

DOI: 10.5451/unibas-003664995 Authors: Adrian Wirz Abstract: The clinical effectiveness of the plant extract of Hypericum perforatum L. in treating mild to moderate depression is well established. The extract shows a more favourable side effect profile than other...

Quantum-annealed machine learning discovers ductile, high strength and corrosion-resistant high-entropy alloy

DOI: 10.1038/s41524-026-02032-x Authors: Diego Ibarra-Hoyos, Peter F. Connors, Ho Jang, Nathan Grain, Israel Klich, Gia-Wei Chern, Peter K. Liaw, John R. Scully, Joseph Poon Abstract: Data scarcity remains a central challenge in materials discovery, where finding...

Elektrospray-Ionisations-Massenspektrometrie als Tool für die qualitative und die quantitative Protein- und Peptidanalytik

DOI: 10.22028/d291-22432 Authors: Bilgin Vatansever Abstract: Aufgrund der immer noch hohen Zahl an offenen Fragenstellungen in den Biowissenschaften gilt die Proteomanalyse als eine der wichtigsten Forschungsgebiete in der Bioanalytik, welche sich intensiv mit der...

Prader-Willi syndrome : genotype and phenotype at adult age

DOI: 10.26481/dis.20111209ms Authors: Margje Sinnema Abstract: Prader-Willi syndrome (PWS) is a genetic disorder caused by the absent expression of the paternal copy of maternally imprinted genes in chromosome region 15q11-13. The frequencies of different subtypes in...

Dissecting the Roles of Dynamic Substructures in Beta-Barrel Containing Coactivators

DOI: 10.7302/2858 Authors: Samantha De Salle Abstract: Starting off the central dogma of genetics, transcription is an integral process in all of life. Transcription is highly regulated, with many players and moving parts, such as transcription factors that localize...