Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters

DOI: 10.1073/pnas.1417047112 Authors: Errol L. G. Samuel, Daniela C. Marcano, Vladimír Berka, Brittany R. Bitner, Gang Wu, Austin Potter, Roderic H. Fabian, Robia G. Pautler, Thomas A. Kent, Ah-Lim Tsai, James M. Tour Abstract: Many diseases are associated with...

The biology and chemistry of high-valent iron–oxo and iron–nitrido complexes

DOI: 10.1038/ncomms1718 Authors: Johannes Hohenberger, Kallol Ray, Karsten Meyer Abstract: N/A

Nitric oxide synthases: structure, function and inhibition

DOI: 10.1042/0264-6021:3570593 Authors: W. Alderton, Chris E. Cooper, Richard G. Knowles Abstract: This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial...

X-ray absorption spectroscopy to watch catalysis by metalloenzymes: status and perspectives discussed for the water-splitting manganese complex of photosynthesis

DOI: 10.1107/s090904950201720x Authors: Holger Dau, Michael Haumann Abstract: Understanding structure-function relations is one of the main interests in the molecular biosciences. X-ray absorption spectroscopy of biological samples (BioXAS) has gained the status of a...

Reaction Mechanism of Hydroxynitrile Lyases of the α/β-Hydrolase Superfamily

DOI: 10.1074/jbc.m401575200 Authors: Karl Gruber, Günter Gartler, Barbara Krammer, Helmut Schwab, Christoph Kratky Abstract: The hydroxynitrile lyases (HNLs) from Hevea brasiliensis (HbHNL) and from Manihot esculenta (MeHNL) are both members of the...

Characterization of Dehaloperoxidase Compound ES and Its Reactivity with Trihalophenols

DOI: 10.1021/bi801916j Authors: J.A. Feducia, Rania Dumarieh, Lauren B. Gilvey, Tatyana I. Smirnova, Stefan Franzen, Reza A. Ghiladi Abstract: Dehaloperoxidase (DHP), the oxygen transport hemoglobin from the terebellid polychaete Amphitrite ornata, is the first globin...

A Rapid Freeze‐Quench Setup for Multi‐Frequency EPR Spectroscopy of Enzymatic Reactions

DOI: 10.1002/cphc.201300714 Authors: Roberta Pievo, Brigitta Angerstein, Alistair J. Fielding, Christian A. Koch, Ivo Feußner, Marina Bennati Abstract: Electron paramagnetic resonance (EPR) spectroscopy in combination with the rapid freeze-quench (RFQ) technique is a...

Effect of freezing conditions on distances and their distributions derived from Double Electron Electron Resonance (DEER): A study of doubly-spin-labeled T4 lysozyme

DOI: 10.1016/j.jmr.2012.01.004 Authors: Elka R. Georgieva, Aritro Sinha Roy, V.M. Grigoryants, Petr P. Borbat, Keith Earle, Charles P. Scholes, Jack H. Freed Abstract: N/A

High-Resolution Extended X-ray Absorption Fine Structure Analysis Provides Evidence for a Longer Fe···Fe Distance in the Q Intermediate of Methane Monooxygenase

DOI: 10.1021/jacs.8b10313 Authors: George E. Cutsail, R. Banerjee, Ang Zhou, Lawrence Que, John D. Lipscomb, Serena DeBeer Abstract: Despite decades of intense research, the core structure of the methane C-H bond breaking diiron(IV) intermediate, Q, of soluble methane...

The Millisecond Intermediate in the Reaction of Nitric Oxide with Oxymyoglobin is an Iron(III)−Nitrato Complex, Not a Peroxynitrite

DOI: 10.1021/ja9026924 Authors: Erik T. Yukl, Simon de Vries, Pierre Moënne‐Loccoz Abstract: The dioxygenation of nitric oxide by oxyheme in globin proteins is a major route for NO detoxification in aerobic biological systems. In myoglobin, this reaction is thought to...