DOI:
Authors:
Yuanmeng Ma, Ruike Li, Yixin Dong, Chaoqun You, Shenlin Huang, Xun Li, Fei Wang, Yu Zhang
Abstract:
Ferritin decorated with tumor-homing penetration peptide tLyP-1 at the N terminal could deliver PTX specifically inside the cell via receptor-mediated endocytosis with better efficacy. The peptide tLyP-1 which is supposed to work only at the C terminus showed enhanced tumor tissue penetration and antitumor efficacy, demonstrating that it also worked at the N-terminal of HFtn.