Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers

DOI: 10.3389/fncel.2015.00287 Authors: A. Zakharov, Carmela Vitale, E. Kilinc, Ksenia Koroleva, Dmitriy Fayuk, Irina V. Shelukhina, Nikolay Naumenko, Andrei Skorinkin, Roustem Khazipov, Rashid Giniatullin Abstract: Trigeminal nerves in meninges are implicated in...

FM1-43 Dye Memorizes Piezo1 Activation in the Trigeminal Nociceptive System Implicated in Migraine Pain

DOI: 10.3390/ijms24021688 Authors: Adriana Della Pietra, Nikita Mikhailov, Rashid Giniatullin Abstract: It has been proposed that mechanosensitive Piezo1 channels trigger migraine pain in trigeminal nociceptive neurons, but the mechanosensitivity of satellite glial...

Negative Cross Talk between Anionic GABA_Aand Cationic P2X Ionotropic Receptors of Rat Dorsal Root Ganglion Neurons

DOI: 10.1523/jneurosci.21-14-04958.2001 Authors: Elena Sokolova, Andrea Nistri, Rashid Giniatullin Abstract: Using whole-cell patch-clamp recording and intracellular Ca(2+) imaging of rat cultured DRG neurons, we studied the cross talk between GABA(A) and P2X...

Ectodomain Movements of an ATP-gated Ion Channel (P2X2 Receptor) Probed by Disulfide Locking

DOI: 10.1074/jbc.m113.542811 Authors: Olga Stelmashenko, Vincent Compan, Liam E. Browne, R. Alan North Abstract: The ectodomain of the P2X receptor is formed mainly from two- or three-stranded β-sheets provided symmetrically by each of the three subunits. These...

Molecular Determinants of Vanilloid Sensitivity in TRPV1

DOI: 10.1074/jbc.m312577200 Authors: Narender R. Gavva, Lana Klionsky, Yusheng Qu, Licheng Shi, Rami Tamir, Steve Edenson, T. J. Zhang, Vellarkad N. Viswanadhan, Attila Tóth, Larry V. Pearce, Todd W. Vanderah, Frank Porreca, Peter M. Blumberg, Jack D. Lile, Yax Sun,...