β3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current

DOI: 10.1172/jci32519 Authors: Vytenis Arvydas Skeberdis, Vida Gendvilieneη, Danguoleη Zablockaiteη, Rimantas Treinys, Regina Macχianskieneη, Andrius Bogdelis, Jonas Jurevicχius, Rodolphe Fischmeister Abstract: beta3-adrenergic receptor (beta3-AR) activation produces...

Mechanisms Mediating the Enhanced Gene Transcription of P2X3 Receptor by Calcitonin Gene-related Peptide in Trigeminal Sensory Neurons

DOI: 10.1074/jbc.m800296200 Authors: Manuela Simonetti, Rashid Giniatullin, Elsa Fabbretti Abstract: The molecular mechanisms underlying migraine pain remain unclear and probably require sustained facilitation in pain-sensing P2X(3) receptors gated by extracellular...

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease

DOI: 10.1016/j.stemcr.2017.10.016 Authors: Minna Oksanen, Andrew J. Petersen, Nikolay Naumenko, Katja A. Puttonen, Šárka Lehtonen, Max Gubert Olivé, Anastasia Shakirzyanova, Stina Leskelä, Timo Sarajärvi, Matti Viitanen, Juha O. Rinne, Mikko Hiltunen, Annakaisa...

Methylglyoxal Evokes Pain by Stimulating TRPA1

DOI: 10.1371/journal.pone.0077986 Authors: David A. Andersson, Clive Gentry, Emily Light, Nisha Vastani, Julie Vallortigara, Angelika Bierhaus, Thomas Fleming, Stuart Bevan Abstract: Diabetic neuropathy is a severe complication of long-standing diabetes and one of the...

Identification of Species-specific Determinants of the Action of the Antagonist Capsazepine and the Agonist PPAHV on TRPV1

DOI: 10.1074/jbc.m313328200 Authors: Elsa Phillips, Alison J. Reeve, Stuart Bevan, Peter McIntyre Abstract: The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. The antagonist,...