Hydrogen Bond Network between Amino Acid Radical Intermediates on the Proton-Coupled Electron Transfer Pathway ofE. coliα2 Ribonucleotide Reductase

DOI: 10.1021/ja510513z Authors: Thomas U. Nick, Wankyu Lee, Simone Koßmann, Frank Neese, JoAnne Stubbe, Marina Bennati Abstract: Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides in all organisms. In all Class Ia RNRs,...

Chemical Nature and Reaction Mechanisms of the Molybdenum Cofactor of Xanthine Oxidoreductase

DOI: 10.2174/1381612811319140010 Authors: Ken Okamoto, Teruo Kusano, Takeshi Nishino Abstract: Xanthine oxidoreductase (XOR), a complex flavoprotein, catalyzes the metabolic reactions leading from hypoxanthine to xanthine and from xanthine to urate, and both reactions...

Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis

DOI: 10.1042/bj1690361 Authors: Daniël J. Steenkamp, Thomas P. Singer Abstract: Bacterial trimethylamine dehydrogenase contains a novel type of covalently bound flavin mononucleotide and a tetrameric iron-sulphur centre. The dehydrogenase takes up 1.5mol of...

Probing Electron Transfer in Flavocytochrome P‐450 BM3 and Its Component Domains

DOI: 10.1111/j.1432-1033.1996.0403u.x Authors: Andrew W. Munro, Simon Daff, John R. Coggins, J. Gordon Lindsay, Stephen K. Chapman Abstract: Rapid events in the processes of electron transfer and substrate binding to cytochrome P-450 BM3 from Bacillus megaterium and...

Overcoming differences: The catalytic mechanism of metallo‐β‐lactamases

DOI: 10.1016/j.febslet.2015.08.015 Authors: María-Rocío Meini, Leticia I. Llarrull, Alejandro J. Vila Abstract: Metallo-β-lactamases are the latest resistance mechanism of pathogenic and opportunistic bacteria against carbapenems, considered as last resort drugs. The...