Characterization of the W321F mutant of Mycobacterium tuberculosis catalase–peroxidase KatG

DOI: 10.1110/ps.09902 Authors: Shengwei Yu, Salem Chouchane, Richard S. Magliozzo Abstract: A single amino acid mutation (W321F) in Mycobacterium tuberculosis catalase-peroxidase (KatG) was constructed by site-directed mutagenesis. The purified mutant enzyme was...

Calcium modulates the rapid kinetics of the odorant-induced cyclic AMP signal in rat olfactory cilia

DOI: 10.1523/jneurosci.15-01-00310.1995 Authors: D. E. Jaworsky, Osamu Matsuzaki, FF Borisy, GV Ronnett Abstract: Although the cAMP and phosphoinositide (PI) second messenger systems are involved in olfactory signal transduction, aspects of their roles remain unclear....

Antibiotic Resistance in Mycobacterium tuberculosis

DOI: 10.1074/jbc.m109.005546 Authors: Javier Suárez, Kalina Ranguelova, Johannes P. M. Schelvis, Richard S. Magliozzo Abstract: KatG (catalase-peroxidase) in Mycobacterium tuberculosis is responsible for activation of isoniazid (INH), a pro-drug used to treat...

Detection, identification, and quantification of oxidative protein modifications

DOI: 10.1074/jbc.rev119.006217 Authors: Clare L. Hawkins, Michael J. Davies Abstract: Exposure of biological molecules to oxidants is inevitable and therefore commonplace. Oxidative stress in cells arises from both external agents and endogenous processes that...

The Reaction of Trimethylamine Dehydrogenase with Trimethylamine

DOI: 10.1074/jbc.274.19.13147 Authors: Mei-Huei Jang, Jaswir Basran, Nigel S. Scrutton, Russ Hille Abstract: The reductive half-reaction of trimethylamine dehydrogenase has been studied using the substrate diethylmethylamine over the pH range 6-10. It is found that...