CW and Pulse EPR of Cytochrome P450 to Determine Structure and Function

DOI: 10.1007/978-3-319-59100-1_5 Authors: Joshua S. Harbort, James J. De Voss, Jeanette E. Stok, Stephen G. Bell, Jeffrey R. Harmer Abstract: N/A

Binuclear Manganese Compounds of Potential Biological Significance. Part 2. Mechanistic Study of Hydrogen Peroxide Disproportionation by Dimanganese Complexes:  The Two Oxygen Atoms of the Peroxide End up in a Dioxo Intermediate

DOI: 10.1021/ic020646n Authors: Lionel Dubois, Régis Caspar, Lilian Jacquamet, P. Petit, Marie‐France Charlot, Carole Baffert, Marie‐Noëlle Collomb, Alain Deronzier, Jean‐Marc Latour Abstract: The dimanganese(II,II) complexes 1a [Mn(2)(L)(OAc)(2)(CH(3)OH)](ClO(4)) and...

Detection of a Kinetically Competent Compound-I Intermediate in the Vancomycin Biosynthetic Enzyme OxyB

DOI: 10.1021/jacs.4c03102 Authors: Andy K. L. Nguy, Ryan J. Martinie, Amanda Cai, Mohammad R. Seyedsayamdost Abstract: Cytochrome P450 enzymes are abundantly encoded in microbial genomes. Their reactions have two general outcomes, one involving oxygen insertion via a...

Biohybrid photosynthetic charge accumulation detected by flavin semiquinone formation in ferredoxin-NADP⁺reductase

DOI: 10.1039/d2sc01546c Authors: Lisa M. Utschig, Udita Brahmachari, Karen L. Mulfort, Jens Niklas, Oleg G. Poluektov Abstract: Flavin chemistry is ubiquitous in biological systems with flavoproteins engaged in important redox reactions. In photosynthesis, flavin...

Probing substrate binding to the metal binding sites in metallo-β-lactamase L1 during catalysis

DOI: 10.1039/c5md00358j Authors: Mahesh Aitha, Sameer Al-Adbul-Wahid, David L. Tierney, Michael W. Crowder Abstract: Metal ions in metallo-β-lactamases (MBLs) play a major role in catalysis. In this study we investigated the role of the metal ions in the Zn1 and Zn2...