Catalysis-dependent selenium incorporation and migration in the nitrogenase active site iron-molybdenum cofactor

DOI: 10.7554/elife.11620 Authors: Thomas Spatzal, Kathryn Perez, James B. Howard, Douglas C. Rees Abstract: Dinitrogen reduction in the biological nitrogen cycle is catalyzed by nitrogenase, a two-component metalloenzyme. Understanding of the transformation of the...

Vascular Consequences of Endothelial Nitric Oxide Synthase Uncoupling for the Activity and Expression of the Soluble Guanylyl Cyclase and the cGMP-Dependent Protein Kinase

DOI: 10.1161/01.atv.0000168896.64927.bb Authors: Thomas Münzel, Andreas Daiber, Volker Ullrich, Alexander Mülsch Abstract: Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolemia, hypertension, diabetes mellitus, chronic...

Millisecond Time-Resolved Solid-State NMR Reveals a Two-Stage Molecular Mechanism for Formation of Complexes between Calmodulin and a Target Peptide from Myosin Light Chain Kinase

DOI: 10.1021/jacs.0c11156 Authors: Jaekyun Jeon, Wai‐Ming Yau, Robert Tycko Abstract: Calmodulin (CaM) mediates a wide range of biological responses to changes in intracellular Ca2+ concentrations through its calcium-dependent binding affinities to numerous target...

Catalytic transformation of dinitrogen into ammonia and hydrazine by iron-dinitrogen complexes bearing pincer ligand

DOI: 10.1038/ncomms12181 Authors: Shogo Kuriyama, Kazuya Arashiba, Kazunari Nakajima, Yuki Matsuo, Hiromasa Tanaka, Kazuyuki Ishii, Kazunari Yoshizawa, Yoshiaki Nishibayashi Abstract: Synthesis and reactivity of iron-dinitrogen complexes have been extensively studied,...

Diiron-cluster intermediates in biological oxygen activation reactions

DOI: 10.1016/s0020-1693(96)05427-8 Authors: Dale E. Edmondson, Boi Hanh Huynh Abstract: N/A