Hydrogen Bond Network between Amino Acid Radical Intermediates on the Proton-Coupled Electron Transfer Pathway ofE. coliα2 Ribonucleotide Reductase

DOI: 10.1021/ja510513z Authors: Thomas U. Nick, Wankyu Lee, Simone Koßmann, Frank Neese, JoAnne Stubbe, Marina Bennati Abstract: Ribonucleotide reductases (RNRs) catalyze the conversion of ribonucleotides to deoxyribonucleotides in all organisms. In all Class Ia RNRs,...

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

DOI: 10.1038/s41467-017-00601-9 Authors: María‐Natalia Lisa, Antonela R. Palacios, Mahesh Aitha, Mariano M. González, Diego M. Moreno, Michael W. Crowder, Robert A. Bonomo, James Spencer, David L. Tierney, Leticia I. Llarrull, Alejandro J. Vila Abstract:...

The Reductive Half-reaction of Xanthine Oxidase

DOI: 10.1074/jbc.274.6.3323 Authors: Min Xia, Robert E. Dempski, Russ Hille Abstract: The kinetics of xanthine oxidase has been investigated with the aim of addressing several outstanding questions concerning the reaction mechanism of the enzyme. Steady-state and...

Mechanistic studies on the dehydrogenases of methylotrophic bacteria. 2. Kinetic studies on the intramolecular electron transfer in trimethylamine and dimethylamine dehydrogenase

DOI: 10.1042/bj2070241 Authors: Daniël J. Steenkamp, Helmut Beinert Abstract: E.p.r. spectroscopy of the trimethylamine and dimethylamine dehydrogenases of Hyphomicrobium X indicates that the substrate-reduced forms of these enzymes exist in the triplet state, which...

Energy transducing redox steps of the Na ⁺ -pumping NADH:quinone oxidoreductase from Vibrio cholerae

DOI: 10.1073/pnas.1002866107 Authors: Oscar Juárez, Joel E. Morgan, Mark J. Nilges, Blanca Barquera Abstract: Na(+)-NQR is a unique respiratory enzyme that couples the free energy of electron transfer reactions to electrogenic pumping of sodium across the cell...