Hunting for origins of migraine pain: cluster analysis of spontaneous and capsaicin-induced firing in meningeal trigeminal nerve fibers

DOI: 10.3389/fncel.2015.00287 Authors: A. Zakharov, Carmela Vitale, E. Kilinc, Ksenia Koroleva, Dmitriy Fayuk, Irina V. Shelukhina, Nikolay Naumenko, Andrei Skorinkin, Roustem Khazipov, Rashid Giniatullin Abstract: Trigeminal nerves in meninges are implicated in...

Identification of Species-specific Determinants of the Action of the Antagonist Capsazepine and the Agonist PPAHV on TRPV1

DOI: 10.1074/jbc.m313328200 Authors: Elsa Phillips, Alison J. Reeve, Stuart Bevan, Peter McIntyre Abstract: The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. The antagonist,...

Methylglyoxal Evokes Pain by Stimulating TRPA1

DOI: 10.1371/journal.pone.0077986 Authors: David A. Andersson, Clive Gentry, Emily Light, Nisha Vastani, Julie Vallortigara, Angelika Bierhaus, Thomas Fleming, Stuart Bevan Abstract: Diabetic neuropathy is a severe complication of long-standing diabetes and one of the...

Mechanisms Mediating the Enhanced Gene Transcription of P2X3 Receptor by Calcitonin Gene-related Peptide in Trigeminal Sensory Neurons

DOI: 10.1074/jbc.m800296200 Authors: Manuela Simonetti, Rashid Giniatullin, Elsa Fabbretti Abstract: The molecular mechanisms underlying migraine pain remain unclear and probably require sustained facilitation in pain-sensing P2X(3) receptors gated by extracellular...

Identification of a Binding Motif in the S5 Helix That Confers Cholesterol Sensitivity to the TRPV1 Ion Channel

DOI: 10.1074/jbc.m111.237537 Authors: Giovanni Picazo-Juárez, Silvina Romero‐Suárez, Andrés Nieto‐Posadas, Itzel Llorente, Andrés Jara-Oseguera, Margaret M. Briggs, Thomas J. McIntosh, Sidney A. Simon, Ernesto Ladrón‐de‐Guevara, León D Islas, Tamara Rosenbaum...