Sulfonylurea receptors set the maximal open probability, ATP sensitivity and plasma membrane density of K_ATP channels

DOI: 10.1016/s0014-5793(99)00102-7 Authors: Andrey P. Babenko, Gabriela González, Lydia Aguilar‐Bryan, Joseph Bryan Abstract: KATP channels are heteromultimers of SUR and KIR6.2. C-terminal truncation of KIR6.2 allows surface expression of the pore. KIR6.2deltaC35...

β3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current

DOI: 10.1172/jci32519 Authors: Vytenis Arvydas Skeberdis, Vida Gendvilieneη, Danguoleη Zablockaiteη, Rimantas Treinys, Regina Macχianskieneη, Andrius Bogdelis, Jonas Jurevicχius, Rodolphe Fischmeister Abstract: beta3-adrenergic receptor (beta3-AR) activation produces...

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer’s Disease

DOI: 10.1016/j.stemcr.2017.10.016 Authors: Minna Oksanen, Andrew J. Petersen, Nikolay Naumenko, Katja A. Puttonen, Šárka Lehtonen, Max Gubert Olivé, Anastasia Shakirzyanova, Stina Leskelä, Timo Sarajärvi, Matti Viitanen, Juha O. Rinne, Mikko Hiltunen, Annakaisa...

Negative Cross Talk between Anionic GABA_Aand Cationic P2X Ionotropic Receptors of Rat Dorsal Root Ganglion Neurons

DOI: 10.1523/jneurosci.21-14-04958.2001 Authors: Elena Sokolova, Andrea Nistri, Rashid Giniatullin Abstract: Using whole-cell patch-clamp recording and intracellular Ca(2+) imaging of rat cultured DRG neurons, we studied the cross talk between GABA(A) and P2X...

FM1-43 Dye Memorizes Piezo1 Activation in the Trigeminal Nociceptive System Implicated in Migraine Pain

DOI: 10.3390/ijms24021688 Authors: Adriana Della Pietra, Nikita Mikhailov, Rashid Giniatullin Abstract: It has been proposed that mechanosensitive Piezo1 channels trigger migraine pain in trigeminal nociceptive neurons, but the mechanosensitivity of satellite glial...