Antimicrobial and anti-inflammatory activities of three chensinin-1 peptides containing mutation of glycine and histidine residues

DOI: 10.1038/srep40228 Authors: Weibing Dong, Xiaoman Mao, Yue Guan, Yao Kang, Dejing Shang Abstract: The natural peptide chensinin-1 doesnot exhibit its desired biological properties. In this study, the mutant MC1-1 was designed by replacing Gly in the chensinin-1...

Restoring speech intelligibility for hearing aid users with deep learning

DOI: 10.1038/s41598-023-29871-8 Authors: Peter U. Diehl, Yosef Singer, Hannes Zilly, Uwe Schönfeld, Paul Meyer-Rachner, Mark Berry, Henning Sprekeler, Elias Sprengel, Annett Pudszuhn, Veit M. Hofmann Abstract: Almost half a billion people world-wide suffer from...

Suppression of FOXM1 Transcriptional Activities via a Single-Stranded DNA Aptamer Generated by SELEX

DOI: 10.1038/srep45377 Authors: Xiang Qin, Guixiang Tan, Xia Jiang, Kuangpei Wu, Weihong Tan, Yongjun Tan Abstract: The transcription factor FOXM1 binds to its consensus sequence at promoters through its DNA binding domain (DBD) and activates proliferation-associated...

Chiral nanocrystals grown from MoS2 nanosheets enable photothermally modulated enantioselective release of antimicrobial drugs

DOI: 10.1038/s41467-022-35016-8 Authors: Bang Lin Li, Jun Jiang Luo, Hao Zou, Qing-Meng Zhang, Liu‐Bin Zhao, Hang Qian, Hong Qun Luo, David Tai Leong, Nian Bing Li Abstract: Abstract The transfer of the concept of chirality from molecules to synthesized nanomaterials...

Effects of nonantibiotic growth promoter combinations on growth performance, nutrient utilization, digestive enzymes, intestinal morphology, and cecal microflora of broilers

DOI: 10.1371/journal.pone.0279950 Authors: Zunyan Li, Beibei Zhang, Weimin Zhu, Lin Yingting, Jia Chen, Fenghua Zhu, Yixuan Guo Abstract: Given the ban on antibiotic growth promoters, the effects of nonantibiotic alternative growth promoter combinations (NAGPCs) on...