β-Amino Acids Reduce Ternary Complex Stability and Alter the Translation Elongation Mechanism

DOI: 10.1021/acscentsci.4c00314 Authors: F. Aaron Cruz-Navarrete, Wezley C. Griffin, Yuk‐Cheung Chan, Maxwell I. Martin, José Luís Pérez Alejo, Ryan A. Brady, S. Kundhavai Natchiar, Isaac J. Knudson, Russ B. Altman, Alanna Schepartz, Scott J. Miller, Scott C....

A Quantitative Method to Distinguish Cytosolic from Endosome‐Trapped Cell‐Penetrating Peptides

DOI: 10.1002/cbic.202400198 Authors: Françoise Illien, Zoltán Bánóczi, Sandrine Sagan Abstract: Cell-penetrating peptides are known to penetrate cells through endocytosis and translocation. The two pathways are hardly distinguished in current cell assays. We developed...

Prebiotic Mannan Oligosaccharide Pretreatment Improves Mice Survival Against Lethal Effects of Gamma Radiation by Protecting GI Tract and Hematopoietic Systems

DOI: 10.3389/fonc.2021.677781 Authors: Sweta Sanguri, Damodar Gupta Abstract: Total body irradiation (TBI) results in critical injuries in a dose dependent manner that primarily damages highly proliferating tissues including hematopoietic stem cells (HSCs) and...

Exploring the challenges of computational enzyme design by rebuilding the active site of a dehalogenase

DOI: 10.1073/pnas.1804979115 Authors: Garima Jindal, Katerina Slanska, Veselin Kolev, Jiřı́ Damborský, Zbyněk Prokop, Arieh Warshel Abstract: Rational enzyme design presents a major challenge that has not been overcome by computational approaches. One of the key...

Insights into the Biosynthesis and Assembly of Cryptophycean Phycobiliproteins

DOI: 10.1074/jbc.m114.591131 Authors: Kristina E. Overkamp, Raphael Gasper, Klaus Kock, Christian Herrmann, Eckhard Hofmann, Nicole Frankenberg‐Dinkel Abstract: Phycobiliproteins are employed by cyanobacteria, red algae, glaucophytes, and cryptophytes for...