A Mechanistic Study on the Destabilization of Whole Inactivated Influenza Virus Vaccine in Gastric Environment

DOI: 10.1371/journal.pone.0066316 Authors: Hyo‐Jick Choi, Charles Ebersbacher, Min‐Chul Kim, Sang‐Moo Kang, Carlo Montemagno Abstract: Oral immunization using whole inactivated influenza virus vaccine promises an efficient vaccination strategy. While oral vaccination...

Crítica a la teoría keynesiana del ciclo económico

DOI: 10.52195/pm.v7i1.288 Authors: David Sanz Bas Abstract: Para solucionar cualquier problema siempre es necesario enten-der previamente cuál es la esencia del mismo, es decir, es nece-sario basarse en una teoría previa que explique por qué ha sur-gido el problema al...

A small single-domain protein folds through the same pathway on and off the ribosome

DOI: 10.1073/pnas.1810517115 Authors: Emily J. Guinn, Pengfei Tian, Mia Shin, Robert B. Best, Susan Marqusee Abstract: In vivo, proteins fold and function in a complex environment subject to many stresses that can modulate a protein’s energy landscape. One...

Antibiotic-induced DNA damage results in a controlled loss of pH homeostasis and genome instability

DOI: 10.1038/s41598-020-76426-2 Authors: James A. Booth, Mário Špı́rek, A. Tekle, Kirsten Skarstad, Lumír Krejčí, Magnar Bjørås Abstract: Extracellular pH has been assumed to play little if any role in how bacteria respond to antibiotics and antibiotic resistance...

CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain

DOI: 10.1042/bj20020604 Authors: Claire Ceni, Nathalie Pochon, Virginie Brun, Hélène Muller‐Steffner, Annie Andrieux, Didier Grünwald, Francis Schuber, Michel De Waard, Frances E. Lund, Michel Villaz, Marie‐Jo Moutin Abstract: CD38 is a transmembrane glycoprotein that...