Single-molecule chemo-mechanical unfolding reveals multiple transition state barriers in a small single-domain protein

DOI: 10.1038/ncomms7861 Authors: Emily J. Guinn, Bharat Jagannathan, Susan Marqusee Abstract: A fundamental question in protein folding is whether proteins fold through one or multiple trajectories. While most experiments indicate a single pathway, simulations suggest...

Metodologia alternativa no manejo da antracnose pós-colheita em Heliconia rostrata

DOI: 10.12661/pap.2014.004 Authors: Luciana Melo Sartori Gurgel, Rildo Sartóri Barbosa Coêlho, Roberto Luiz Xavier da Silva, Sônia Maria Alves de Oliveira, Regina Ceres Torres da Rosa, Tereza Cristina de Assis, Domingos Eduardo Guimarães Tavares de Andrade Abstract: A...

Mycobacterial and Human Ferrous Nitrobindins: Spectroscopic and Reactivity Properties

DOI: 10.3390/ijms22041674 Authors: Giovanna De Simone, Alessandra di Masi, Alessandra Pesce, Martino Bolognesi, Chiara Ciaccio, Lorenzo Tognaccini, Giulietta Smulevich, Stefania Abbruzzetti, Cristiano Viappiani, Stefano Bruno, Sara Della Monaca, Donatella Pietraforte,...

IMPAIRMENT OF URIC ACID EXCRETION IN GOUT*

DOI: 10.1172/jci104653 Authors: Willoughby Lathem, Gerald P. Rodnan Abstract: The urinary excretion and renal clearance of uric acid were determined in 10 nongouty control subjects and in 11 patients with primary gout. The nongouty subjects, all but two of whom (M.W....

Large enhancement of response times of a protein conformational switch by computational design

DOI: 10.1038/s41467-018-03228-6 Authors: Alex J. DeGrave, Jeung‐Hoi Ha, Stewart N. Loh, Lillian T. Chong Abstract: The design of protein conformational switches-or proteins that change conformations in response to a signal such as ligand binding-has great potential...