Partial rescue of F508del‐cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual‐acting small molecule

DOI: 10.1111/bph.14141 Authors: Jia Liu, Hermann Bihler, Carlos M. Farinha, Nikhil T Awatade, Ana M. Romão, Dayna L. Mercadante, Yi Cheng, Isaac Musisi, Walailak Jantarajit, Yi‐Ting Wang, Zhiwei Cai, Margarida D. Amaral, Martin Mense, David N. Sheppard Abstract:...

A High Throughput Aqueous Passivation Testing Methodology for Compositionally Complex Alloys Using a Scanning Droplet Cell

DOI: 10.1149/1945-7111/aceeb8 Authors: Debashish Sur, Howie Joress, Jason Hattrick‐Simpers, John R. Scully Abstract: Compositionally complex alloys containing four or more principal elements provide an opportunity to explore a wide range of compositions, processing,...

Purkinje Cell Activity Resonation Generates Rhythmic Behaviors at the Preferred Frequency of 8 Hz

DOI: 10.3390/biomedicines10081831 Authors: Staf Bauer, Nathalie van Wingerden, Thomas Jacobs, Annabel van der Horst, Peipei Zhai, Jan-Harm L. F. Betting, Christos Strydis, Joshua J. White, Chris I. De Zeeuw, Vincenzo Romano Abstract: Neural activity exhibits...

SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

DOI: 10.1101/2021.01.06.425392 Authors: Jiří Zahradník, Shir Marciano, Maya Shemesh, Eyal Zoler, Jeanne Chiaravalli, Bjoern Meyer, Yinon Rudich, Orly Dym, Nadav Elad, Gideon Schreiber Abstract: Abstract SARS-CoV-2 is continually evolving, with more contagious...

Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity

DOI: 10.1016/j.ejmech.2020.112116 Authors: Lionel Froux, Ahmad Elbahnsi, Benjamin Boucherle, Arnaud Billet, Nesrine Baatallah, Brice Hoffmann, Julien Alliot, Renaud Zelli, Waël Zeinyeh, Romain Haudecoeur, B. Chevalier, Antoine Fortuné, Sandra Mirval, Christophe...