Antisense Oligonucleotide Therapy to Correct CFTR Function in People with Cystic Fibrosis

DOI: 10.26182/qe32-qt58 Authors: Kelly M. Martinovich Abstract: Cystic fibrosis (CF) is the most common life-threatening recessively inherited disease in Caucasians that has no cure. Novel therapeutics such as antisense oligonucleotides (AOs) have potential to be...

CFTR correctors potentiate gating mutants causing cystic fibrosis

DOI: 10.1016/j.jcf.2025.11.008 Authors: Solène Castanier, Ahmad Elbahnsi, B. Chevalier, Lynda Berri, Madara Dias Wickramanayaka, Jean-Paul Mornon, Aurélie Hatton, Isabelle Sermet‐Gaudelus, Aleksander Edelman, Isabelle Callebaut, Alexandre Hinzpeter Abstract: The...

SLX4 dampens MutSα-dependent mismatch repair

DOI: 10.1101/2021.10.12.464076 Authors: Jean-Hugues Guervilly, Marion Blin, Luisa Laureti, Émilie Baudelet, Stéphane Audebert, Pierre-Henri L. Gaillard Abstract: ABSTRACT The tumour suppressor SLX4 plays multiple roles in the maintenance of genome stability, acting as...

Topography-Guided Custom Ablation Treatment for Post-Traumatic Corneal Irregularities—Case Reports

DOI: 10.3390/biomedicines13081818 Authors: Łukasz Drzyzga, Dorota Śpiewak, Mariola Dorecka, Dorota Wyględowska‐Promieńska Abstract: Background: Post-traumatic corneal wounds that require suturing are quite common; they reduce corneal transparency and cause corneal...

SARS-CoV-2 RBD in vitro evolution parrots and predicts contagious mutation spread

DOI: 10.21203/rs.3.rs-183310/v1 Authors: Gideon Schreiber, Jiří Zahradník, Shir Marciano, Maya Shemesh, Eyal Zoler, Jeanne Chiaravalli, Bjoern Meyer, Yinon Rudich, Orly Dym, Nadav Elad Abstract: Abstract SARS-CoV-2 is continually evolving, with more contagious...