Protocol of the IntenSify-Trial: An open-label phase I trial of the CYP3A inhibitor cobicistat and the cytostatics gemcitabine and nab-paclitaxel in patients with advanced stage or metastatic pancreatic ductal adenocarcinoma to evaluate the combination’s pharmacokinetics, safety, and efficacy.

DOI: 10.1111/cts.13661 Authors: Hohmann N, Sprick MR, Pohl M, Ahmed A, Burhenne J, Kirchner M, Le Cornet L, Kratzmann M, Hajda J, Stenzinger A, Steindorf K, Delorme S, Schlemmer HP, Riethdorf S, van Schaik R, Pantel K, Siveke J, Seufferlein T, Jäger D, Haefeli WE,...

Adaptation and acclimation of hotosynthetic machinery in Arabidopsis thaliana

DOI: OA:W7120436329 Authors: Laura Laihonen Abstract: Photosynthetic organisms convert physical energy from the sun into chemical energy through photosynthetic light reactions catalysed by thylakoid membrane-embedded pigment-protein complexes. Four major protein...

The algal PETC-Pro171-Leu suppresses electron transfer in the cytochrome b ₆ f complex under acidic lumenal condition

DOI: 10.1101/2021.12.15.472847 Authors: Shin‐Ichiro Ozawa, Félix Buchert, Ruby Reuys, Michael Hippler, Yuichiro Takahashi Abstract: Abstract Linear photosynthetic electron flow (LEF) produces NADPH and generates a proton electrochemical potential gradient across the...

Cryo-EM structure of Chlamydomonas Photosystem I complexed with the alternative electron donor cytochrome c6

DOI: 10.21203/rs.3.rs-7585678/v1 Authors: Jan M. Schuller, Yu Ogawa, Gyana Prakash Mahapatra, Yuval Milrad, Michelle Schimpf, Genji Kurisu, Michael Hippler Abstract: N/A

Simultaneous Measurement of Gross Oxygen Evolution and Underlying Photosynthetic Redox Reactions: A Case Study Using Cyanobacteria

DOI: 10.1101/2024.10.03.616403 Authors: Oded Liran Abstract: Abstract In phytoplankton, the intricate balance between respiration and photosynthesis is co-regulated to ensure efficient energy management and adaptation to varying environmental conditions. In...