{"id":961,"date":"2026-04-15T12:58:17","date_gmt":"2026-04-15T12:58:17","guid":{"rendered":"https:\/\/citations.tools.bio-logic.fr\/?p=961"},"modified":"2026-04-15T12:58:17","modified_gmt":"2026-04-15T12:58:17","slug":"partial-rescue-of-f508del%e2%80%90cystic-fibrosis-transmembrane-conductance-regulator-channel-gating-with-modest-improvement-of-protein-processing-but-not-stability-by-a-dual%e2%80%90acting-small-mo","status":"publish","type":"post","link":"https:\/\/citations.tools.bio-logic.fr\/?p=961","title":{"rendered":"Partial rescue of F508del\u2010cystic fibrosis transmembrane conductance regulator channel gating with modest improvement of protein processing, but not stability, by a dual\u2010acting small molecule"},"content":{"rendered":"<h4>DOI:<\/h4>\n<p><a href=\"https:\/\/doi.org\/10.1111\/bph.14141\" target=\"_blank\" rel=\"noopener\">10.1111\/bph.14141<\/a><\/p>\n<h4>Authors:<\/h4>\n<p>Jia Liu, Hermann Bihler, Carlos M. Farinha, Nikhil T Awatade, Ana M. Rom\u00e3o, Dayna L. Mercadante, Yi Cheng, Isaac Musisi, Walailak Jantarajit, Yi\u2010Ting Wang, Zhiwei Cai, Margarida D. Amaral, Martin Mense, David N. Sheppard<\/p>\n<h4>Abstract:<\/h4>\n<p>CFFT-004 is a dual-acting small molecule with independent corrector and potentiator activities that partially rescues F508del-CFTR in recombinant cells and native airway epithelia. The limited efficacy and potency of CFFT-004 suggests that combinations of small molecules targeting different defects in F508del-CFTR might be a more effective therapeutic strategy than a single agent.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DOI: 10.1111\/bph.14141 Authors: Jia Liu, Hermann Bihler, Carlos M. Farinha, Nikhil T Awatade, Ana M. Rom\u00e3o, Dayna L. Mercadante, Yi Cheng, Isaac Musisi, Walailak Jantarajit, Yi\u2010Ting Wang, Zhiwei Cai, Margarida D. Amaral, Martin Mense, David N. Sheppard Abstract: CFFT-004 is a dual-acting small molecule with independent corrector and potentiator activities that partially rescues F508del-CFTR in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-961","post","type-post","status-publish","format-standard","hentry","category-m-470-ac-dc-sds"],"_links":{"self":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/961","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=961"}],"version-history":[{"count":0,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/961\/revisions"}],"wp:attachment":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=961"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=961"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=961"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}