{"id":778,"date":"2026-04-15T13:14:19","date_gmt":"2026-04-15T13:14:19","guid":{"rendered":"https:\/\/citations.tools.bio-logic.fr\/?p=778"},"modified":"2026-04-15T13:14:19","modified_gmt":"2026-04-15T13:14:19","slug":"microglial-amyloid-beta-clearance-is-driven-by-piezo1-channels","status":"publish","type":"post","link":"https:\/\/citations.tools.bio-logic.fr\/?p=778","title":{"rendered":"Microglial amyloid beta clearance is driven by PIEZO1 channels"},"content":{"rendered":"<h4>DOI:<\/h4>\n<p><a href=\"https:\/\/doi.org\/10.1186\/s12974-022-02486-y\" target=\"_blank\" rel=\"noopener\">10.1186\/s12974-022-02486-y<\/a><\/p>\n<h4>Authors:<\/h4>\n<p>Henna J\u00e4ntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Irene F. Ugidos, Mireia G\u00f3mez\u2010Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya, Mohammad Feroze Fazaludeen, Nikita Mikhailov, Maria Gotkiewicz, Kirsi Ketola, \u0160\u00e1rka Lehtonen, Jari Ko\u0131st\u0131naho, Katja M. Kanninen, Dami\u00e1n Hern\u00e1ndez, Alice P\u00e9bay, Rosalba Giugno, Paula Korhonen, Rashid Giniatullin, Tarja Malm<\/p>\n<h4>Abstract:<\/h4>\n<p>These results indicate that the compromised function of microglia in AD could be improved by controlled activation of PIEZO1 channels resulting in alleviated A\u03b2 burden. Pharmacological regulation of these mechanoreceptors in microglia could represent a novel therapeutic paradigm for AD.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DOI: 10.1186\/s12974-022-02486-y Authors: Henna J\u00e4ntti, Valeriia Sitnikova, Yevheniia Ishchenko, Anastasia Shakirzyanova, Luca Giudice, Irene F. Ugidos, Mireia G\u00f3mez\u2010Budia, Nea Korvenlaita, Sohvi Ohtonen, Irina Belaya, Mohammad Feroze Fazaludeen, Nikita Mikhailov, Maria Gotkiewicz, Kirsi Ketola, \u0160\u00e1rka Lehtonen, Jari Ko\u0131st\u0131naho, Katja M. Kanninen, Dami\u00e1n Hern\u00e1ndez, Alice P\u00e9bay, Rosalba Giugno, Paula Korhonen, Rashid Giniatullin, Tarja Malm Abstract: These results [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-778","post","type-post","status-publish","format-standard","hentry","category-rsc-200"],"_links":{"self":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/778","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=778"}],"version-history":[{"count":0,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/778\/revisions"}],"wp:attachment":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=778"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=778"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=778"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}