10.1016\/j.stemcr.2017.10.016<\/a><\/p>\nAuthors:<\/h4>\n
Minna Oksanen, Andrew J. Petersen, Nikolay Naumenko, Katja A. Puttonen, \u0160\u00e1rka Lehtonen, Max Gubert Oliv\u00e9, Anastasia Shakirzyanova, Stina Leskel\u00e4, Timo Saraj\u00e4rvi, Matti Viitanen, Juha O. Rinne, Mikko Hiltunen, Annakaisa Haapasalo, Rashid Giniatullin, Pasi Tavi, Su\u2010Chun Zhang, Katja M. Kanninen, Riikka H. H\u00e4m\u00e4l\u00e4inen, Jari Ko\u0131st\u0131naho<\/p>\n
Abstract:<\/h4>\n
Alzheimer’s disease (AD) is a common neurodegenerative disorder and the leading cause of cognitive impairment. Due to insufficient understanding of the disease mechanisms, there are no efficient therapies for AD. Most studies have focused on neuronal cells, but astrocytes have also been suggested to contribute to AD pathology. We describe here the generation of functional astrocytes from induced pluripotent stem cells (iPSCs) derived from AD patients with PSEN1 \u0394E9 mutation, as well as healthy and gene-corrected isogenic controls. AD astrocytes manifest hallmarks of disease pathology, including increased \u03b2-amyloid production, altered cytokine release, and dysregulated Ca2+<\/sup> homeostasis. Furthermore, due to altered metabolism, AD astrocytes show increased oxidative stress and reduced lactate secretion, as well as compromised neuronal supportive function, as evidenced by altering Ca2+<\/sup> transients in healthy neurons. Our results reveal an important role for astrocytes in AD pathology and highlight the strength of iPSC-derived models for brain diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"DOI: 10.1016\/j.stemcr.2017.10.016 Authors: Minna Oksanen, Andrew J. Petersen, Nikolay Naumenko, Katja A. Puttonen, \u0160\u00e1rka Lehtonen, Max Gubert Oliv\u00e9, Anastasia Shakirzyanova, Stina Leskel\u00e4, Timo Saraj\u00e4rvi, Matti Viitanen, Juha O. Rinne, Mikko Hiltunen, Annakaisa Haapasalo, Rashid Giniatullin, Pasi Tavi, Su\u2010Chun Zhang, Katja M. Kanninen, Riikka H. H\u00e4m\u00e4l\u00e4inen, Jari Ko\u0131st\u0131naho Abstract: Alzheimer’s disease (AD) is a common neurodegenerative […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21],"tags":[],"class_list":["post-773","post","type-post","status-publish","format-standard","hentry","category-rsc-200"],"_links":{"self":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/773","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=773"}],"version-history":[{"count":0,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/773\/revisions"}],"wp:attachment":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=773"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=773"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=773"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}