10.1183\/13993003\/erj.38.suppl_55.p2022<\/a><\/p>\nAuthors:<\/h4>\n
Emilia Viklund, A. Lindblad, P. Robinson, B. Houltz, L. Bergh, Monika Rosberg, P. Gustafsson<\/p>\n
Abstract:<\/h4>\n
Background:
\n The lung clearance index (LCI) obtained from SF6 multiple breath washout (MBW) is a sensitive index of peripheral airway dysfunction in cystic fibrosis (CF) [1]. SF6 LCI values are lower and show stronger agreement between laboratories than historical N2 LCI using conventional N2 analyzers [1]. Formal comparison between the two types of MBW systems has not been performed to date. This study compared FRC and LCI obtained using both methods: mass spectrometer SF6 MBW and a new indirect N2 MBW system (Exhalyser D, EcoMedics, Duernten, Switzerland) in CF subjects.<\/p>\n
Methods:
\n 10 CF subjects, median (range) 17 (15-40) yrs performed MBW in triplicate using an SF6-based mass spectrometer MBW system and an Exhalyzer D indirect N2-based MBW system (main stream infrared CO2 sensor, side stream laser O2 sensor). FRC and LCI were calculated using similar software algorithms. Results expressed as mean (SD) and between-test comparisons made using students t-tests.<\/p>\n
Results:
\n There was no significant difference between FRC values (N2 FRC 2.82 (0.71) vs. SF6 FRC 2.53 (0.70), p=0.37), however N2 LCI, 12.52 (3.14), was significantly higher than SF6 LCI, 9.77 (2.46) (p=0.043). Within-session repeatability (coefficient of variation, CV%) did not differ between the groups: N2 FRC 6.8 (2.9)% vs. SF6 FRC 5.5 (3.1)%, and N2 LCI CV 5.0 (3.6)% vs. SF6 LCI CV 4.7 (2.8)%.<\/p>\n
Conclusions:
\n LCI values obtained with the new indirect N2 MBW system were greater than those obtained with the current gold standard SF6 mass spectrometer based system. FRC values and within-session repeatability were similar.<\/p>\n
References:<\/p>\n
1
\n Robinson PD et al. European Respiratory Monograph; 2010. p. 87-104.<\/p>\n","protected":false},"excerpt":{"rendered":"
DOI: 10.1183\/13993003\/erj.38.suppl_55.p2022 Authors: Emilia Viklund, A. Lindblad, P. Robinson, B. Houltz, L. Bergh, Monika Rosberg, P. Gustafsson Abstract: Background: The lung clearance index (LCI) obtained from SF6 multiple breath washout (MBW) is a sensitive index of peripheral airway dysfunction in cystic fibrosis (CF) [1]. SF6 LCI values are lower and show stronger agreement between laboratories […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-213","post","type-post","status-publish","format-standard","hentry","category-sec2020"],"_links":{"self":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/213","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=213"}],"version-history":[{"count":0,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/213\/revisions"}],"wp:attachment":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=213"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=213"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}