{"id":1533,"date":"2025-12-23T10:37:08","date_gmt":"2025-12-23T10:37:08","guid":{"rendered":"https:\/\/citations.tools.bio-logic.fr\/?p=1533"},"modified":"2025-12-23T10:37:08","modified_gmt":"2025-12-23T10:37:08","slug":"improved-in-vitro-test-procedure-for-full-assessment-of-the-cytocompatibility-of-degradable-magnesium-based-on-iso-10993-5-12","status":"publish","type":"post","link":"https:\/\/citations.tools.bio-logic.fr\/?p=1533","title":{"rendered":"Improved In Vitro Test Procedure for Full Assessment of the Cytocompatibility of Degradable Magnesium Based on ISO 10993-5\/-12"},"content":{"rendered":"<h4>DOI:<\/h4>\n<p><a href=\"https:\/\/doi.org\/10.3390\/ijms20020255\" target=\"_blank\" rel=\"noopener\">10.3390\/ijms20020255<\/a><\/p>\n<h4>Authors:<\/h4>\n<p>Ole Jung, Ralf Smeets, Philip Hartjen, Reinhard Schnettler, Frank Feyerabend, Martin Klein, Nils Wegner, Frank Walther, Dominic Stangier, Anders Henningsen, Carsten Rendenbach, Max Heiland, Mike Barbeck, Alexander Kopp<\/p>\n<h4>Abstract:<\/h4>\n<p>Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and the related (micro-) milieu conditions pretend to strictly follow in vitro standards based on ISO 10993-5\/-12. Thus, special adaptions for the testing of Mg materials are necessary, which have been described in a previous study from our group. Based on these adaptions, further developments of a test procedure allowing rapid and effective in vitro cytocompatibility analyses of Mg-based materials based on ISO 10993-5\/-12 are necessary. The following study introduces a new two-step test scheme for rapid and effective testing of Mg. Specimens with different surface characteristics were produced by means of plasma electrolytic oxidation (PEO) using silicate-based and phosphate-based electrolytes. The test samples were evaluated for corrosion behavior, cytocompatibility and their mechanical and osteogenic properties. Thereby, two PEO ceramics could be identified for further in vivo evaluations.<\/p>\n","protected":false},"excerpt":{"rendered":"<h4>DOI:<\/h4>\n<div class=\"b-doi\">10.3390\/ijms20020255<\/div>\n<h4>Authors:<\/h4>\n<div class=\"b-author\">Ole Jung, Ralf Smeets, Philip Hartjen, Reinhard Schnettler, Frank Feyerabend, Martin Klein, Nils Wegner, Frank Walther, Dominic Stangier, Anders Henningsen, Carsten Rendenbach, Max Heiland, Mike Barbeck, Alexander Kopp<\/div>\n<h4>Abstract:<\/h4>\n<div class=\"b-intro\">Magnesium (Mg)-based biomaterials are promising candidates for bone and tissue regeneration. Alloying and surface modifications provide effective strategies for optimizing and tailoring their degradation kinetics. Nevertheless, biocompatibility analyses of Mg-based materials are challenging due to its special degradation mechanism with continuous hydrogen release. In this context, the hydrogen release and&hellip;<\/div>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[25],"tags":[37],"class_list":["post-1533","post","type-post","status-publish","format-standard","hentry","category-sp-150-potentiostat","tag-corrosion"],"_links":{"self":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/1533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1533"}],"version-history":[{"count":0,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/1533\/revisions"}],"wp:attachment":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}