10.3389\/fbioe.2021.780197.s001<\/a><\/p>\nAuthors:<\/h4>\n
Venkata Suresh Vajrala (11759081), Valentin Saunier (11759084), Lionel G. Nowak (11759087), Emmanuel Flahaut (2012314), Christian Bergaud (1530010), Ali Maziz (1418584)<\/p>\n
Abstract:<\/h4>\n
<p>In this study, we report a flexible implantable 4-channel microelectrode probe coated with highly porous and robust nanocomposite of poly (3,4-ethylenedioxythiophene) (PEDOT) and carbon nanofiber (CNF) as a solid doping template for high-performance in vivo neuronal recording and stimulation. A simple yet well-controlled deposition strategy was developed via in situ electrochemical polymerization technique to create a porous network of PEDOT and CNFs on a flexible 4-channel gold microelectrode probe. Different morphological and electrochemical characterizations showed that they exhibit remarkable and superior electrochemical properties, yielding microelectrodes combining high surface area, low impedance (16.8 \u00b1 2 M\u2126 \u00b5m<sup>2<\/sup> at 1 kHz) and elevated charge injection capabilities (7.6 \u00b1 1.3 mC\/cm<sup>2<\/sup>) that exceed those of pure and composite PEDOT layers. In addition, the PEDOT-CNF composite electrode exhibited extended biphasic charge cycle endurance and excellent performance under accelerated lifetime testing, resulting in a negligible physical delamination and\/or degradation for long periods of electrical stimulation. In vitro testing on mouse brain slices showed that they can record spontaneous oscillatory field potentials as well as single-unit action potentials and allow to safely deliver electrical stimulation for evoking field potentials. The combined superior electrical properties, durability and 3D microstructure topology of the PEDOT-CNF composite electrodes demonstrate outstanding potential for developing future neural surface interfacing applications.<\/p><\/p>\n","protected":false},"excerpt":{"rendered":"
DOI: 10.3389\/fbioe.2021.780197.s001 Authors: Venkata Suresh Vajrala (11759081), Valentin Saunier (11759084), Lionel G. Nowak (11759087), Emmanuel Flahaut (2012314), Christian Bergaud (1530010), Ali Maziz (1418584) Abstract: <p>In this study, we report a flexible implantable 4-channel microelectrode probe coated with highly porous and robust nanocomposite of poly (3,4-ethylenedioxythiophene) (PEDOT) and carbon nanofiber (CNF) as a solid doping template […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"class_list":["post-1200","post","type-post","status-publish","format-standard","hentry","category-vsp-3-potentiostat"],"_links":{"self":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/1200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1200"}],"version-history":[{"count":0,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=\/wp\/v2\/posts\/1200\/revisions"}],"wp:attachment":[{"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/citations.tools.bio-logic.fr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}